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Emergence of young human genes after a burst of retroposition in primates

Abstract:

The origin of new genes through gene duplication is fundamental to the evolution of lineage- or species-specific phenotypic traits. In this report, we estimate the number of functional retrogenes on the lineage leading to humans generated by the high rate of retroposition (retroduplication) in primates. Extensive comparative sequencing and expression studies coupled with evolutionary analyses and simulations suggest that a significant proportion of recent retrocopies represent bona fide human...

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Journal:
PLoS Biology
Volume:
3
Issue:
11
Pages:
1970-1979
Publication date:
2005-11-01
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
Language:
English
Pubs id:
pubs:345444
UUID:
uuid:c63d014e-081b-430b-b50a-e2b7c4664d79
Local pid:
pubs:345444
Source identifiers:
345444
Deposit date:
2013-11-16

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