Journal article
Inhibition of human ovarian carcinoma cell- and hexosaminidase- mediated degradation of extracellular matrix by sugar analogs.
- Abstract:
-
Human ovarian carcinoma (HOC) cell beta-N-acetylglucosaminidase (beta-NAG, EC 3.2.1.30) was found to be present in three isoenzymatic forms. All three forms were capable of degrading ECM. Therefore, inhibitors of beta-NAG were sought as potential anti-invasive agents. Two sugar analogs, 2-acetamido-2-deoxy-1,5-gluconolactone (CD80110) and 2-acetamido-1,5-imino-1,2,5-trideoxy-D-glucitol (CD 86022), were evaluated for their ability to inhibit 1) human ovarian carcinoma beta-NAG isoenzyme activi...
Expand abstract
- Publication status:
- Published
Actions
Authors
Bibliographic Details
- Journal:
- Anticancer research
- Volume:
- 12
- Issue:
- 1
- Pages:
- 161-166
- Publication date:
- 1992-01-01
- EISSN:
-
1791-7530
- ISSN:
-
0250-7005
- Source identifiers:
-
43808
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:43808
- UUID:
-
uuid:c63b1d3c-8430-4c3c-9c08-bedb8f021790
- Local pid:
- pubs:43808
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1992
If you are the owner of this record, you can report an update to it here: Report update to this record