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Journal article

Inhibition of human ovarian carcinoma cell- and hexosaminidase- mediated degradation of extracellular matrix by sugar analogs.

Abstract:

Human ovarian carcinoma (HOC) cell beta-N-acetylglucosaminidase (beta-NAG, EC 3.2.1.30) was found to be present in three isoenzymatic forms. All three forms were capable of degrading ECM. Therefore, inhibitors of beta-NAG were sought as potential anti-invasive agents. Two sugar analogs, 2-acetamido-2-deoxy-1,5-gluconolactone (CD80110) and 2-acetamido-1,5-imino-1,2,5-trideoxy-D-glucitol (CD 86022), were evaluated for their ability to inhibit 1) human ovarian carcinoma beta-NAG isoenzyme activi...

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Publication status:
Published

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Journal:
Anticancer research
Volume:
12
Issue:
1
Pages:
161-166
Publication date:
1992-01-01
EISSN:
1791-7530
ISSN:
0250-7005
Source identifiers:
43808
Language:
English
Keywords:
Pubs id:
pubs:43808
UUID:
uuid:c63b1d3c-8430-4c3c-9c08-bedb8f021790
Local pid:
pubs:43808
Deposit date:
2012-12-19

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