Activation and Function of Interferon Regulatory Factor 5.

Journal article

Interferon regulatory factor 5 (IRF5) is a crucial transcription factor in a number of immune and homeostatic processes, including host defense against pathogens, tumorigenesis, and autoimmunity. Upon induction of immune signaling pathways, IRF5 undergoes post-translational modifications such as phosphorylation and ubiqutination, which are believed to trigger IRF5 nuclear translocation from the cytosol, followed by recruitment to promoters where transcription of its gene targets is initiated....

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Authors: Ryzhakov, G; Eames, H; Udalova, I

• Journal: Journal of interferon and cytokine research : the official journal of the International Society for Interferon and Cytokine Research
• Pages: 140926135928001-140926135928001
• Publication date: 2014-09-01
• DOI: 10.1089/jir.2014.0023
• EISSN: 1557-7465
• ISSN: 1079-9907
• Language: English