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Design of spectral-spatial outer volume suppression RF pulses for tissue specific metabolic characterization with hyperpolarized 13C pyruvate.

Abstract:

[1-(13)C] pyruvate pre-polarized via DNP has been used in animal models to probe changes in metabolic enzyme activities in vivo. To more accurately assess the metabolic state and its change from disease progression or therapy in a specific region or tissue in vivo, it may be desirable to separate the downstream (13)C metabolite signals resulting from the metabolic activity within the tissue of interest and those brought into the tissue by perfusion. In this study, a spectral-spatial saturatio...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmr.2009.06.021

Authors


Vigneron, DB More by this author
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Journal:
Journal of magnetic resonance (San Diego, Calif. : 1997)
Volume:
200
Issue:
2
Pages:
344-348
Publication date:
2009-10-05
DOI:
EISSN:
1096-0856
ISSN:
1090-7807
URN:
uuid:c6316111-c459-4b38-affd-2de9f5e554d7
Source identifiers:
441913
Local pid:
pubs:441913

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