Journal article
Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model
- Abstract:
-
The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic encephalopathy, and the relationships between these disorders, are poorly understood. We examined post-mortem brains from teenage athletes in the acute-subacute period after mild closed-head impact injury and found astrocytosis, myelinated axonopathy, microvascular injury, perivascular neuroinflammation, and phosphorylated tau protein pathology. To investigate causal mechanisms, we developed a mouse model of...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Brain Journal website
- Volume:
- 141
- Issue:
- 2
- Pages:
- 422-458
- Publication date:
- 2018-01-18
- Acceptance date:
- 2017-10-29
- DOI:
- EISSN:
-
1460-2156
- ISSN:
-
0006-8950
- Pmid:
-
29360998
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:821436
- UUID:
-
uuid:c628f72f-6b3a-4819-bf5c-34254db9c469
- Local pid:
- pubs:821436
- Source identifiers:
-
821436
- Deposit date:
- 2019-05-09
Terms of use
- Copyright holder:
- Tagge et al
- Copyright date:
- 2018
- Notes:
- © The Authors (2018). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
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