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Journal article

Parameter-free methods distinguish Wnt pathway models and guide design of experiments

Abstract:

The canonical Wnt signaling pathway, mediated by β-catenin, is crucially involved in development, adult stem cell tissue maintenance, and a host of diseases including cancer. We analyze existing mathematical models of Wnt and compare them to a new Wnt signaling model that targets spatial localization; our aim is to distinguish between the models and distill biological insight from them. Using Bayesian methods we infer parameters for each model from mammalian Wnt signaling data and find that a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1416655112

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
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Funding agency for:
MacLean, A
Grant:
KUK-C1-013-04
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Funding agency for:
MacLean, A
Grant:
KUK-C1-013-04
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Funding agency for:
Byrne, H
Grant:
KUK-C1-013-04
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Funding agency for:
Byrne, H
Grant:
KUK-C1-013-04
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Funding agency for:
Harrington, H
Grant:
KUK-C1-013-04
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
112
Issue:
9
Pages:
2652-2657
Publication date:
2015-03-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
510003
Language:
English
Keywords:
Pubs id:
pubs:510003
UUID:
uuid:c611a3d1-fd8b-4cee-ab03-ecd1be304338
Local pid:
pubs:510003
Deposit date:
2015-03-12

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