Journal article
Parameter-free methods distinguish Wnt pathway models and guide design of experiments
- Abstract:
-
The canonical Wnt signaling pathway, mediated by β-catenin, is crucially involved in development, adult stem cell tissue maintenance, and a host of diseases including cancer. We analyze existing mathematical models of Wnt and compare them to a new Wnt signaling model that targets spatial localization; our aim is to distinguish between the models and distill biological insight from them. Using Bayesian methods we infer parameters for each model from mammalian Wnt signaling data and find that a...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1073/pnas.1416655112
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Authors
Funding
+ Human Frontiers in Science
More from this funder
Funding agency for:
MacLean, A
Grant:
KUK-C1-013-04
+ King Abdullah University of Science and Technology
More from this funder
Funding agency for:
MacLean, A
Grant:
KUK-C1-013-04
+ Human Frontiers in Science
More from this funder
Funding agency for:
Byrne, H
Grant:
KUK-C1-013-04
+ King Abdullah University of Science and Technology
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Funding agency for:
Byrne, H
Grant:
KUK-C1-013-04
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Harrington, H
Grant:
KUK-C1-013-04
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Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 112
- Issue:
- 9
- Pages:
- 2652-2657
- Publication date:
- 2015-03-01
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
510003
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:510003
- UUID:
-
uuid:c611a3d1-fd8b-4cee-ab03-ecd1be304338
- Local pid:
- pubs:510003
- Deposit date:
- 2015-03-12
Terms of use
- Copyright holder:
- MacLean et al
- Copyright date:
- 2015
- Notes:
- Copyright © MacLean et al. National Academy of Sciences of the United States of America retains an exclusive license to publish.
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