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Mechanical stimulation of the pro-angiogenic capacity of human fracture haematoma: involvement of VEGF mechano-regulation.

Abstract:

Compromised angiogenesis appears to be a major limitation in various suboptimal bone healing situations. Appropriate mechanical stimuli support blood vessel formation in vivo and improve healing outcomes. However, the mechanisms responsible for this association are unclear. To address this question, the paracrine angiogenic potential of early human fracture haematoma and its responsiveness to mechanical loading, as well as angiogenic growth factors involved, were investigated in vitro. Human ...

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Publication status:
Published

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Publisher copy:
10.1016/j.bone.2010.05.026

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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Role:
Author
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Journal:
Bone
Volume:
47
Issue:
2
Pages:
438-444
Publication date:
2010-08-05
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
URN:
uuid:c60a02e9-d617-4497-a84e-37e09eda53aa
Source identifiers:
66216
Local pid:
pubs:66216

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