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Journal article

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin

Abstract:

Accurate read-out of chromatin modifications is essential for eukaryotic life. Mutations in the gene encoding X-linked ATRX protein cause a mental-retardation syndrome, whereas wild-type ATRX protein targets pericentric and telomeric heterochromatin for deposition of the histone variant H3.3 by means of a largely unknown mechanism. Here we show that the ADD domain of ATRX, in which most syndrome-causing mutations occur, engages the N-terminal tail of histone H3 through two rigidly oriented bi...

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Publisher copy:
10.1038/nsmb.2070

Authors


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Journal:
Nature Structural and Molecular Biology
Volume:
18
Issue:
7
Pages:
777-782
Publication date:
2011-07-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Source identifiers:
253824
Language:
English
Pubs id:
pubs:253824
UUID:
uuid:c5f9b459-2b4a-4f2d-97f6-4623131ec296
Local pid:
pubs:253824
Deposit date:
2012-12-19

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