Journal article
Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin
- Abstract:
-
Accurate read-out of chromatin modifications is essential for eukaryotic life. Mutations in the gene encoding X-linked ATRX protein cause a mental-retardation syndrome, whereas wild-type ATRX protein targets pericentric and telomeric heterochromatin for deposition of the histone variant H3.3 by means of a largely unknown mechanism. Here we show that the ADD domain of ATRX, in which most syndrome-causing mutations occur, engages the N-terminal tail of histone H3 through two rigidly oriented bi...
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- Publisher copy:
- 10.1038/nsmb.2070
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Authors
Bibliographic Details
- Journal:
- Nature Structural and Molecular Biology
- Volume:
- 18
- Issue:
- 7
- Pages:
- 777-782
- Publication date:
- 2011-07-01
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- Source identifiers:
-
253824
Item Description
- Language:
- English
- Pubs id:
-
pubs:253824
- UUID:
-
uuid:c5f9b459-2b4a-4f2d-97f6-4623131ec296
- Local pid:
- pubs:253824
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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