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Precision modulation of neurodegenerative disease-related gene expression in human iPSC-derived neurons

Abstract:

The ability to reprogram adult somatic cells into induced pluripotent stem cells (iPSCs) and the subsequent development of protocols for their differentiation into disease-relevant cell types have enabled in-depth molecular analyses of multiple disease states as hitherto impossible. Neurons differentiated from patient-specific iPSCs provide a means to recapitulate molecular phenotypes of neurodegenerative diseases in vitro. However, it remains challenging to conduct precise manipulations of g...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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10.1038/srep28420

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Pages:
Article: 28420
Publication date:
2016-06-24
Acceptance date:
2016-05-16
DOI:
Pubs id:
pubs:730241
URN:
uri:c5f6c94b-6598-41f8-ae4c-28b37d9afc2a
UUID:
uuid:c5f6c94b-6598-41f8-ae4c-28b37d9afc2a
Local pid:
pubs:730241

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