Abnormal intracellular calcium homeostasis in sympathetic neurons from young prehypertensive rats

Journal article

Hypertension is associated with cardiac noradrenergic hyperactivity, although it is not clear whether this precedes or follows the development of hypertension itself. We hypothesized that Ca homeostasis in postganglionic sympathetic neurons is impaired in spontaneously hypertensive rats (SHRs) and may occur before the development of hypertension. The depolarization-induced rise in intracellular free calcium concentration ([Ca]i; measured using fura-2-acetoxymethyl ester) was significantly lar...

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Authors: Li, D; Lee, C; Buckler, K; Parekh, A; Herring, N

• Journal: Hypertension
• Volume: 59
• Issue: 3
• Pages: 642-649
• Publication date: 2012-03-01
• DOI: 10.1161/HYPERTENSIONAHA.111.186460
• EISSN: 1524-4563
• ISSN: 0194-911X
• Language: English
• Keywords: hypertension; calcium homeostasis; mitochondria; endoplasmic reticulum; sympathetic neuron