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Type I and III interferon in the gut: tight balance between host protection and immunopathology

Abstract:

The intestinal mucosa forms an active interface to the outside word, facilitating nutrient and water uptake and at the same time acts as a barrier toward the highly colonized intestinal lumen. A tight balance of the mucosal immune system is essential to tolerate harmless antigens derived from food or commensals and to effectively defend against potentially dangerous pathogens. Interferons (IFN) provide a first line of host defense when cells detect an invading organism. Whereas type I IFN wer...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2017.00258

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Role:
Author
ORCID:
0000-0003-0229-9010
More from this funder
Funding agency for:
Pott, J
Grant:
MR/N02379X/1
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
8
Issue:
MAR
Article number:
258
Publication date:
2017-03-14
Acceptance date:
2017-02-21
DOI:
ISSN:
1664-3224
Pmid:
28352268
Language:
English
Keywords:
Pubs id:
pubs:696314
UUID:
uuid:c5f4761a-cf0f-4d2b-9e56-3628a8d1503d
Local pid:
pubs:696314
Source identifiers:
696314
Deposit date:
2018-01-08

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