Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning
Background: A major challenge in the application of marrow transplantation as a route to immunological tolerance of a transplanted organ is to achieve hematopoietic stem cell (HSC) engraftment with minimal myelosuppressive treatments.Expand abstract
Results: We here describe a combined antibody protocol which can achieve long-term engraftment with clinically relevant doses of MHC-mismatched bone marrow, without the need for myelosuppressive drugs. Alt...
- Publication status:
- Peer review status:
- Peer reviewed
- Copyright holder:
- Graca et al
- Copyright date:
- © 2006 Graca et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- CC Attribution (CC BY)
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