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Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning

Abstract:

Background: A major challenge in the application of marrow transplantation as a route to immunological tolerance of a transplanted organ is to achieve hematopoietic stem cell (HSC) engraftment with minimal myelosuppressive treatments.

Results: We here describe a combined antibody protocol which can achieve long-term engraftment with clinically relevant doses of MHC-mismatched bone marrow, without the need for myelosuppressive drugs. Alt...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1186/1471-2172-7-9

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Publisher:
BioMed Central Publisher's website
Journal:
BMC Immunology Journal website
Volume:
7
Article number:
9
Publication date:
2006-04-25
Acceptance date:
2006-04-25
DOI:
EISSN:
1471-2172
Source identifiers:
11576
Language:
English
Keywords:
Pubs id:
pubs:11576
UUID:
uuid:c5f2c719-03ff-40b8-8aa0-e74dc0c3c4f2
Local pid:
pubs:11576
Deposit date:
2012-12-19

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