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Human bone-derived cells support formation of human osteoclasts from arthroplasty-derived cells in vitro.

Abstract:

Mononuclear osteoclast precursors are present in the wear-particle-associated macrophage infiltrate found in the membrane surrounding loose implants. These cells are capable of differentiating into osteoclastic bone-resorbing cells when co-cultured with the rat osteoblast-like cell line, UMR 106, in the presence of 1,25(OH)2 vitamin D3. In order to develop an in vitro model of osteoclast differentiation which more closely parallels the cellular microenvironment at the bone-implant interface i...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
The Journal of bone and joint surgery. British volume
Volume:
82
Issue:
6
Pages:
892-900
Publication date:
2000-08-05
DOI:
ISSN:
0301-620X
URN:
uuid:c5ef3c14-c648-4419-b463-94a4680a54b0
Source identifiers:
62388
Local pid:
pubs:62388

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