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Genomic epidemiology reconstructs the introduction and spread of Zika virus in Central America and Mexico

Abstract:

The Zika virus (ZIKV) epidemic in the Americas established ZIKV as a major public health threat and uncovered its association with severe diseases, including microcephaly. However, genetic epidemiology in some at-risk regions, particularly Central America and Mexico, remains limited. We report 61 ZIKV genomes from this region, generated using metagenomic sequencing with ZIKV-specific enrichment, and combine phylogenetic, epidemiological, and environmental data to reconstruct ZIKV transmission...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.chom.2018.04.017

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Bouquet, J More by this author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
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Oxford Martin School More from this funder
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Grant:
T32HD040128
R01LM010812
R01LM011965
R01AI099631
P01AI106695
U19 AI118610
R21AI129455
R01 HL105704
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Publisher:
Cell Press Publisher's website
Journal:
Cell Host and Microbe Journal website
Volume:
23
Issue:
6
Pages:
855-864.e7
Publication date:
2018-05-24
Acceptance date:
2018-04-26
DOI:
EISSN:
1934-6069
ISSN:
1931-3128
Pubs id:
pubs:844882
URN:
uri:c5ee16d3-9842-4bdc-ae75-994edebe52cb
UUID:
uuid:c5ee16d3-9842-4bdc-ae75-994edebe52cb
Local pid:
pubs:844882

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