Differential activation of microglia in neurogenic versus non-neurogenic regions of the forebrain.

Journal article

Proliferation decreases in the neurogenic subventricular zone (SVZ) of mice after aspiration lesions of the cerebral cortex. We hypothesized that microglial activation may contribute to this given microglial activation attenuates neurogenesis in the hippocampus. Using CD45, CD11b, IB4, and IL-6 immunohistochemistry (IHC), BrdU IHC, and fluorescent bead tracking of peripheral monocytes into the brain, we compared microglial activation in the SVZ to non-neurogenic forebrain regions. SVZ microgl...

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Authors: Goings, G; Kozlowski, D; Szele, F

• Publication status: Published
• Journal: Glia
• Volume: 54
• Issue: 4
• Pages: 329-342
• Publication date: 2006-09-01
• DOI: 10.1002/glia.20381
• EISSN: 1098-1136
• ISSN: 0894-1491
• Language: English
• Keywords: Immunohistochemistry; Animals; Tissue Fixation; Fluorescent Dyes; Macrophages; Antimetabolites; Bromodeoxyuridine; Choroid Plexus; Male; Cerebral Cortex; Microspheres; Diagnostic Imaging; Cell Proliferation; Microglia; Cerebral Ventricles; Brain Injuries; Prosencephalon; Mice