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Differential activation of microglia in neurogenic versus non-neurogenic regions of the forebrain.

Abstract:

Proliferation decreases in the neurogenic subventricular zone (SVZ) of mice after aspiration lesions of the cerebral cortex. We hypothesized that microglial activation may contribute to this given microglial activation attenuates neurogenesis in the hippocampus. Using CD45, CD11b, IB4, and IL-6 immunohistochemistry (IHC), BrdU IHC, and fluorescent bead tracking of peripheral monocytes into the brain, we compared microglial activation in the SVZ to non-neurogenic forebrain regions. SVZ microgl...

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Publication status:
Published

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Publisher copy:
10.1002/glia.20381

Authors


Goings, GE More by this author
Kozlowski, DA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Glia
Volume:
54
Issue:
4
Pages:
329-342
Publication date:
2006-09-05
DOI:
EISSN:
1098-1136
ISSN:
0894-1491
URN:
uuid:c5e9c609-ec97-42e9-b4a3-f3978ff78301
Source identifiers:
113313
Local pid:
pubs:113313

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