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Identification of oncostatin M as a STAT5-dependent mediator of bone marrow remodeling in KIT D816V-positive systemic mastocytosis.

Abstract:

Systemic mastocytosis is a neoplastic disease of mast cells harboring the activating KIT mutation D816V. In most patients, mast cell infiltration in the bone marrow is accompanied by marked microenvironment alterations, including increased angiogenesis, osteosclerosis, and sometimes fibrosis. Little is known about the mast cell-derived molecules contributing to these bone marrow alterations. We show here that neoplastic mast cells in patients with systemic mastocytosis express oncostatin M (O...

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Journal:
The American journal of pathology
Volume:
178
Issue:
5
Pages:
2344-2356
Publication date:
2011-05-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:c5e7fdde-fe87-4f91-9bef-be9f3d774430
Source identifiers:
489982
Local pid:
pubs:489982

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