Journal article
Identification of oncostatin M as a STAT5-dependent mediator of bone marrow remodeling in KIT D816V-positive systemic mastocytosis.
- Abstract:
-
Systemic mastocytosis is a neoplastic disease of mast cells harboring the activating KIT mutation D816V. In most patients, mast cell infiltration in the bone marrow is accompanied by marked microenvironment alterations, including increased angiogenesis, osteosclerosis, and sometimes fibrosis. Little is known about the mast cell-derived molecules contributing to these bone marrow alterations. We show here that neoplastic mast cells in patients with systemic mastocytosis express oncostatin M (O...
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- Publisher copy:
- 10.1016/j.ajpath.2011.01.020
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Authors
Bibliographic Details
- Journal:
- American journal of pathology
- Volume:
- 178
- Issue:
- 5
- Pages:
- 2344-2356
- Publication date:
- 2011-05-01
- DOI:
- EISSN:
-
1525-2191
- ISSN:
-
0002-9440
- Source identifiers:
-
489982
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:489982
- UUID:
-
uuid:c5e7fdde-fe87-4f91-9bef-be9f3d774430
- Local pid:
- pubs:489982
- Deposit date:
- 2014-11-22
Terms of use
- Copyright date:
- 2011
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