A population-dynamic model for evaluating the potential spread of drug-resistant influenza virus infections during community-based use of antivirals.

Journal article

A mathematical model of influenza transmission dynamics is used to simulate the impact of neuraminidase inhibitor therapy on infection rates and transmission of drug-resistant viral strains. The model incorporates population age structure, seasonal transmission, immunity and inclusion of elderly nursing home residents or non-residents. Key parameter values are estimated from epidemiological, clinical and experimental data. The analysis examines the factors determining the population spread of...

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Authors: Ferguson, N; Mallett, S; Jackson, H; Roberts, N; Ward, P

• Publication status: Published
• Journal: Journal of antimicrobial chemotherapy
• Volume: 51
• Issue: 4
• Pages: 977-990
• Publication date: 2003-04-01
• DOI: 10.1093/jac/dkg136
• EISSN: 1460-2091
• ISSN: 0305-7453
• Language: English
• Keywords: Female; Humans; Antiviral Agents; Models, Statistical; Orthomyxoviridae; Influenza, Human; Forecasting; Drug Resistance, Viral; Middle Aged; Adult; Algorithms; Population; Aged; Adolescent; Age Factors; Male