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Journal article

Metabolomics reveals distinct, antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease

Abstract:

The overlapping clinical features of relapsing remitting multiple sclerosis (RRMS), aquaporin-4 (AQP4)-antibody (Ab) neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein (MOG)-Ab disease mean that detection of disease specific serum antibodies is the gold standard in diagnostics. However, antibody levels are not prognostic and may become undetectable after treatment or during remission. Therefore, there is still a need to discover antibody-independent biomar...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s40478-017-0495-8

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Role:
Author
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Ministry of Health, Singapore More from this funder
More from this funder
Grant:
Confidence in Concept Fund
Polish Ministry of Science and Higher Education More from this funder
Multiple Sclerosis Society of Great Britain More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Acta Neuropathologica Communications Journal website
Volume:
5
Pages:
95
Publication date:
2017-12-06
Acceptance date:
2017-11-14
DOI:
EISSN:
2051-5960
Source identifiers:
834427
Keywords:
Pubs id:
pubs:834427
UUID:
uuid:c5d9f374-fd61-4937-a6f8-c32caa4b5c04
Local pid:
pubs:834427
Deposit date:
2018-04-09

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