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Drosophila Uri, a PPIα binding protein, is essential for viability, maintenance of DNA integrity and normal transcriptional activity

Abstract:

Background: Protein phosphatase 1 (PP1) is involved in diverse cellular processes, and is targeted to substrates via interaction with many different protein binding partners. PP1 catalytic subunits (PP1c) fall into PP1α and PP1β subfamilies based on sequence analysis, however very few PP1c binding proteins have been demonstrated to discriminate between PP1α and PP1β. Results: URI (unconventional prefoldin RPB5 interactor) is a conserved molecular chaperone implicated in a variety of cellular ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2199-9-36

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Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology
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Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology
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Institution:
"Abbott Laboratories, Global Pharmaceutical Regulatory Affairs, Abbott Park, IL, USA", "University of Oxford"
Department:
Mathematical,Physical & Life Sciences Division - Zoology
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Institution:
"University of Edinburgh", "University of Oxford"
Department:
Mathematical,Physical & Life Sciences Division - Zoology
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Institution:
"Harvard University", "University of Oxford"
Department:
Mathematical,Physical & Life Sciences Division - Zoology
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Funding agency for:
Luke Alphey
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Funding agency for:
Helen White-Cooper
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC Molecular Biology Journal website
Volume:
9
Pages:
Article: 36
Publication date:
2008-04-05
DOI:
ISSN:
1471-2199
URN:
uuid:c5c74763-16f1-416c-b36b-2664a27ba985
Local pid:
ora:3052
Language:
English
Subjects:

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