Journal article icon

Journal article

Transcriptional activation of the general amino acid permease gene per1 by the histone deacetylase Clr6 Is regulated by Oca2 kinase.

Abstract:

Expression of nitrogen metabolism genes is regulated by the quality of the nitrogen supply. Here, we describe a mechanism for the transcriptional regulation of the general amino acid permease gene per1 in Schizosaccharomyces pombe. We show that when ammonia is used as the nitrogen source, low levels of per1 are transcribed and histones in the coding and surrounding regions of per1 are acetylated. In the presence of proline, per1 transcription is upregulated and initiates from a more upstream ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1128/mcb.00971-09

Authors


Expand authors...
Journal:
Molecular and cellular biology
Volume:
30
Issue:
13
Pages:
3396-3410
Publication date:
2010-07-01
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
Source identifiers:
60438

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP