Journal article
A single CD4 test with 250 cells/mm3 threshold predicts viral suppression in HIV-infected adults failing first-line therapy by clinical criteria
- Abstract:
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BACKGROUND: In low-income countries, viral load (VL) monitoring of antiretroviral therapy (ART) is rarely available in the public sector for HIV-infected adults or children. Using clinical failure alone to identify first-line ART failure and trigger regimen switch may result in unnecessary use of costly second-line therapy. Our objective was to identify CD4 threshold values to confirm clinically-determined ART failure when VL is unavailable. METHODS: 3316 HIV-infected Ugandan/Zimbabwean adult...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 465.8KB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0057580
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Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS ONE More from this journal
- Volume:
- 8
- Issue:
- 2
- Pages:
- e57580
- Publication date:
- 2013-02-21
- Acceptance date:
- 2013-01-23
- DOI:
- EISSN:
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1932-6203
Item Description
- Language:
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English
- Keywords:
- UUID:
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uuid:c5c20b7c-e5da-4b0b-8c4b-9307df082413
- Local pid:
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pubs:422595
- Source identifiers:
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422595
- Deposit date:
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2014-02-08
Terms of use
- Copyright holder:
- Gilks et al
- Copyright date:
- 2013
- Notes:
- © 2013 Gilks et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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