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Journal article

CC chemokine receptors and chronic inflammation--therapeutic opportunities and pharmacological challenges.

Abstract:

Chemokines are a family of low molecular weight proteins with an essential role in leukocyte trafficking during both homeostasis and inflammation. The CC class of chemokines consists of at least 28 members (CCL1-28) that signal through 10 known chemokine receptors (CCR1-10). CC chemokine receptors are expressed predominantly by T cells and monocyte-macrophages, cell types associated predominantly with chronic inflammation occurring over weeks or years. Chronic inflammatory diseases including ...

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Publication status:
Published

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Publisher copy:
10.1124/pr.111.005074

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
Role:
Author
Publisher:
American Society for Pharmacology and Experimental Therapy
Journal:
Pharmacological reviews
Volume:
65
Issue:
1
Pages:
47-89
Publication date:
2013-01-05
DOI:
EISSN:
1521-0081
ISSN:
0031-6997
URN:
uuid:c5b88418-ad14-4e1e-8e5d-5eb2f451b4eb
Source identifiers:
374210
Local pid:
pubs:374210

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