Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic.

Journal article

BACKGROUND: Recent clinical trials in the Lao People's Democratic Republic have demonstrated that chloroquine and sulfadoxine-pyrimethamine, which are national malaria treatment policy, are no longer effective in the treatment of uncomplicated Plasmodium falciparum malaria. METHODS: A randomized comparison of 3 oral antimalarial combinations--chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine--with 42-day follow-up period, was conducte...

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Authors: Mayxay, M; Khanthavong, M; Lindegårdh, N; Keola, S; Barends, M

• Publication status: Published
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• Volume: 39
• Issue: 8
• Pages: 1139-1147
• Publication date: 2004-10-01
• DOI: 10.1086/424512
• EISSN: 1537-6591
• ISSN: 1058-4838
• Language: English
• Keywords: Artemisinins; Drug Therapy, Combination; Female; Drug Combinations; Pyrimethamine; Male; Ethanolamines; Antimalarials; Child, Preschool; Child; Infant; Laos; Chloroquine; Humans; Mefloquine; Sulfadoxine; Malaria, Falciparum; Adult; Sesquiterpenes; Fluorenes; Adolescent