- Abstract:
-
The minichromosome maintenance (MCM) helicase is the presumptive replicative helicase in archaea and eukaryotes. The archaeal homomultimeric MCM has a two-tier structure. One tier contains the AAA+ motor domains of the proteins, and these are the minimal functional helicase domains. The second tier is formed by the N-terminal domains. These domains are not essential for MCM helicase activity but act to enhance the processivity of the helicase. We reveal that a conserved loop facilitates commu...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.0809192106
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 106
- Issue:
- 4
- Pages:
- 1051-1056
- Publication date:
- 2009-01-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:c5a70f90-236d-435d-811f-c3a5f077a4da
- Source identifiers:
-
25329
- Local pid:
- pubs:25329
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Intersubunit allosteric communication mediated by a conserved loop in the MCM helicase.
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