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Intersubunit allosteric communication mediated by a conserved loop in the MCM helicase.

Abstract:

The minichromosome maintenance (MCM) helicase is the presumptive replicative helicase in archaea and eukaryotes. The archaeal homomultimeric MCM has a two-tier structure. One tier contains the AAA+ motor domains of the proteins, and these are the minimal functional helicase domains. The second tier is formed by the N-terminal domains. These domains are not essential for MCM helicase activity but act to enhance the processivity of the helicase. We reveal that a conserved loop facilitates commu...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0809192106

Authors


Lovett, JE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
4
Pages:
1051-1056
Publication date:
2009-01-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:c5a70f90-236d-435d-811f-c3a5f077a4da
Source identifiers:
25329
Local pid:
pubs:25329

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