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Journal article

Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis.

Abstract:

Osteoclasts are bone-eroding cells that develop from monocytic precursor cells in the presence of receptor activator of NF-kappaB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF). Osteoclasts are essential for physiological bone remodeling, but localized excessive osteoclast activity is responsible for the periarticular bone destruction that characteristically occurs in patients with rheumatoid arthritis (RA). The origin of osteoclasts at sites of bone erosion in RA is unknown....

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1000546107

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
107
Issue:
29
Pages:
13028-13033
Publication date:
2010-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:c5a6cb3f-7901-4f8b-9277-4eef9da37447
Source identifiers:
375296
Local pid:
pubs:375296

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