Journal article
Single-cell studies of IFN-beta promoter activation by wildtype and NS1-defective influenza A viruses
- Abstract:
-
Deletion or truncation of NS1, the principal interferon (IFN) antagonist of influenza viruses, leads to increased IFN induction during influenza virus infection. We have studied activation of the IFN induction cascade by both wildtype and NS1-defective viruses at the single-cell level using a cell line expressing GFP under the control of the IFN-β promoter and by examining MxA expression. The IFN-β promoter was not activated in all infected cells, even during NS1-defective virus infections. L...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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- Files:
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(pdf, 4.0MB)
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- Publisher copy:
- 10.1099/jgv.0.000687
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Authors
Funding
Bibliographic Details
- Publisher:
- Microbiology Society Publisher's website
- Journal:
- Journal of General Virology Journal website
- Volume:
- 98
- Pages:
- 357-363
- Publication date:
- 2017-01-01
- Acceptance date:
- 2016-12-14
- DOI:
- EISSN:
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1465-2099
- ISSN:
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0022-1317
- Pubs id:
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pubs:666008
- URN:
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uri:c5a1bf77-a71f-4f60-b250-3391166e5687
- UUID:
-
uuid:c5a1bf77-a71f-4f60-b250-3391166e5687
- Local pid:
- pubs:666008
Item Description
Terms of use
- Copyright holder:
- Killip et al.
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 The Authors.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution and reproduction in any medium, provided the original
author and source are credited.
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