Single-cell studies of IFN-beta promoter activation by wildtype and NS1-defective influenza A viruses
Deletion or truncation of NS1, the principal interferon (IFN) antagonist of influenza viruses, leads to increased IFN induction during influenza virus infection. We have studied activation of the IFN induction cascade by both wildtype and NS1-defective viruses at the single-cell level using a cell line expressing GFP under the control of the IFN-β promoter and by examining MxA expression. The IFN-β promoter was not activated in all infected cells, even during NS1-defective virus infections. L...Expand abstract
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- Journal of General Virology Journal website
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- Killip et al.
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Copyright © 2017 The Authors.
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