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Single-cell studies of IFN-beta promoter activation by wildtype and NS1-defective influenza A viruses

Abstract:

Deletion or truncation of NS1, the principal interferon (IFN) antagonist of influenza viruses, leads to increased IFN induction during influenza virus infection. We have studied activation of the IFN induction cascade by both wildtype and NS1-defective viruses at the single-cell level using a cell line expressing GFP under the control of the IFN-β promoter and by examining MxA expression. The IFN-β promoter was not activated in all infected cells, even during NS1-defective virus infections. L...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1099/jgv.0.000687

Authors


Killip, MJ More by this author
Jackson, D More by this author
Perez-Cidoncha, M More by this author
More by this author
Department:
Exeter College
Randall, RE More by this author
Publisher:
Microbiology Society Publisher's website
Journal:
Journal of General Virology Journal website
Volume:
98
Pages:
357-363
Publication date:
2017
Acceptance date:
2016-12-14
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
Pubs id:
pubs:666008
URN:
uri:c5a1bf77-a71f-4f60-b250-3391166e5687
UUID:
uuid:c5a1bf77-a71f-4f60-b250-3391166e5687
Local pid:
pubs:666008

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