Potential for synthesis and degradation of extracellular matrix proteins by valve interstitial cells seeded onto collagen scaffolds.

Journal article

Matrix remodeling, which involves proteolytic enzymes, such as the matrix metalloproteinases (MMPs), is of significant importance with respect to tissue engineering a heart valve construct. The ability of valve interstitial cells (ICs) to release these enzymes in biological scaffolds and to synthesize their own matrix has not been adequately studied, and this has important implications for tissue engineering. Cultured human aortic valve ICs were seeded onto a 3-dimensional type I collagen mat...

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Authors: Dreger, SA; Thomas, P; Sachlos, E; Chester, A; Czernuszka, J

• Publication status: Published
• Journal: Tissue engineering
• Volume: 12
• Issue: 9
• Pages: 2533-2540
• Publication date: 2006-09-01
• DOI: 10.1089/ten.2006.12.2533
• EISSN: 1557-8690
• ISSN: 1076-3279
• Language: English
• Keywords: Connective Tissue Cells; Humans; Cell Culture Techniques; Heart Valve Prosthesis; Extracellular Matrix; Extracellular Matrix Proteins; Biocompatible Materials; Matrix Metalloproteinases; Cells, Cultured; Aortic Valve; Gene Expression Regulation, Enzymologic; Tissue Engineering; Bioprosthesis