Journal article
EGF-coated gold nanoparticles provide an efficient nano-scale delivery system for the molecular radiotherapy of EGFR-positive cancer.
- Abstract:
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Purpose Radiolabeled antibodies and peptides hold promise for molecular radiotherapy but are often limited by a low payload resulting in inadequate delivery of radioactivity to tumour tissue and, therefore, modest therapeutic effect. We developed a facile synthetic method of radiolabeling indium-111 ((111)In) to epidermal growth factor (EGF)-gold nanoparticles ((111)In-EGF-Au NP) with a high payload. Materials and methods EGF-Au NP were prepared via an interaction between gold and the disulph...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 1.3MB)
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- Publisher copy:
- 10.3109/09553002.2016.1145360
Authors
Funding
Medical Research Council and the CR-UK Oxford Cancer
Imaging Centre
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Bibliographic Details
- Publisher:
- Taylor and Francis Publisher's website
- Journal:
- International journal of radiation biology Journal website
- Pages:
- 1-8
- Publication date:
- 2016-01-01
- Acceptance date:
- 2016-01-18
- DOI:
- EISSN:
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1362-3095
- ISSN:
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0955-3002
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:611660
- UUID:
-
uuid:c59b4bf6-f93f-4428-9d0c-11bbed535e9f
- Local pid:
- pubs:611660
- Source identifiers:
-
611660
- Deposit date:
- 2016-04-21
Terms of use
- Copyright holder:
- Song et al
- Copyright date:
- 2016
- Notes:
- Copyright © 2015 The Author(s). Published by Informa UK Limited, trading as Taylor and Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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