Journal article icon

Journal article

EGF-coated gold nanoparticles provide an efficient nano-scale delivery system for the molecular radiotherapy of EGFR-positive cancer.

Abstract:

Purpose Radiolabeled antibodies and peptides hold promise for molecular radiotherapy but are often limited by a low payload resulting in inadequate delivery of radioactivity to tumour tissue and, therefore, modest therapeutic effect. We developed a facile synthetic method of radiolabeling indium-111 ((111)In) to epidermal growth factor (EGF)-gold nanoparticles ((111)In-EGF-Au NP) with a high payload. Materials and methods EGF-Au NP were prepared via an interaction between gold and the disulph...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.3109/09553002.2016.1145360

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
Medical Research Council and the CR-UK Oxford Cancer Imaging Centre More from this funder
Publisher:
Taylor and Francis Publisher's website
Journal:
International journal of radiation biology Journal website
Pages:
1-8
Publication date:
2016-01-01
DOI:
EISSN:
1362-3095
ISSN:
0955-3002
URN:
uuid:c59b4bf6-f93f-4428-9d0c-11bbed535e9f
Source identifiers:
611660
Local pid:
pubs:611660

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP