Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas.

Journal article

Inappropriate expression of HLA Class II (D/DR) molecules has been detected in the target cells of most autoimmune diseases including Type I (insulin-dependent) diabetes. The possibility that this phenomenon is due to the action of lymphocytes or some of their products has been investigated by analysing in vitro the modulation of HLA products in Beta cells. Monolayer cultures from 25 human pancreatic glands were supplemented with alpha-interferon (IFN), beta-IFN or gamma-IFN, interleukin 2 (I...

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Authors: Pujol-Borrell, R; Todd, I; Doshi, M; Gray, D; Feldmann, M

• Publication status: Published
• Journal: Clinical and experimental immunology
• Volume: 65
• Issue: 1
• Pages: 128-139
• Publication date: 1986-07-01
• EISSN: 1365-2249
• ISSN: 0009-9104
• Language: English
• Keywords: Pancreatitis; Cells, Cultured; Humans; Pancreas; Major Histocompatibility Complex; Interferon-gamma; Interferon Type I; Islets of Langerhans; HLA-DR Antigens; Fluorescent Antibody Technique; Diabetes Mellitus, Type 1; Interleukin-2; Lectins; HLA Antigens