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Selective dendritic localization of mRNA in Drosophila mushroom body output neurons.

Abstract:

Memory-relevant neuronal plasticity is believed to require local translation of new proteins at synapses. Understanding this process requires the visualization of the relevant mRNAs within these neuronal compartments. Here, we used single-molecule fluorescence in situ hybridization to localize mRNAs at subcellular resolution in the adult Drosophila brain. mRNAs for subunits of nicotinic acetylcholine receptors and kinases could be detected within the dendrites of co-labeled mushroom bo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.62770

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Institution:
University of Oxford
Division:
MSD
Sub department:
Biochemistry
Role:
Author
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Role:
Author
ORCID:
0000-0001-9713-4088
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Role:
Author
ORCID:
0000-0002-7281-8026
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Grant:
107457/Z/15/Z
RG62710 (Cambridge Ref)
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
10
Article number:
e62770
Publication date:
2021-03-16
Acceptance date:
2021-03-15
DOI:
EISSN:
2050-084X
Pmid:
33724180
Language:
English
Keywords:
Pubs id:
1168493
Local pid:
pubs:1168493
Deposit date:
2021-08-04

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