Journal article
Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation
- Abstract:
-
Plasmacytoid dendritic cells (pDCs) produce type I interferon (IFN-I) and are traditionally defined as being BDCA 2+CD123+. pDC are not readily detectable in healthy human skin, but have been suggested to accumulate in wounds. Here, we describe a CD1a bearing BDCA-2+CD123int DC subset that rapidly infiltrates human skin wounds and comprises a major DC population. Using single-cell RNA sequencing, we show that these cells are largely activated DC acquiring features compatible with lymph node h...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Rockefeller University Press Publisher's website
- Journal:
- Journal of Experimental Medicine Journal website
- Volume:
- 217
- Issue:
- 3
- Article number:
- e20190811
- Publication date:
- 2019-12-17
- Acceptance date:
- 2019-11-12
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1071865
- UUID:
-
uuid:c58ed192-eb0a-43fd-a0e0-ae51e57ba3c7
- Local pid:
- pubs:1071865
- Source identifiers:
-
1071865
- Deposit date:
- 2019-11-14
Terms of use
- Copyright holder:
- Chen et al.
- Copyright date:
- 2019
- Rights statement:
- © 2019 Chen et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
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