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Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories

Abstract:

Balance of cortical excitation and inhibition (EI) is thought to be disrupted in several neuropsychiatric conditions, yet it is not clear how it is maintained in the healthy human brain. When EI balance is disturbed during learning and memory in animal models, it can be restabilized via formation of inhibitory replicas of newly formed excitatory connections. Here we assess evidence for such selective inhibitory rebalancing in humans. Using fMRI repetition suppression we measure newly formed c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.neuron.2016.02.031

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Publisher:
Elsevier
Journal:
Neuron More from this journal
Volume:
90
Issue:
1
Pages:
191-203
Publication date:
2016-03-17
Acceptance date:
2016-02-24
DOI:
ISSN:
1097-4199 and 0896-6273
Pmid:
26996082

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