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Human RECQL5 Helicase; A Target Enabling Package

Abstract:

RECQL5 is a member of the RecQ family of helicase which have important functions in DNA repair pathways and maintenance of genome integrity. RECQL5 has recently been identified as a synthetic lethal candidate in various haematological malignancies and has been verified by knockdown to sensitize myeloproliferative neoplasms (MPN) to DNA damaging agents. In this TEP we have expressed purified and determined the first ever crystal structures of RECQL5, in both APO and ADP/Mg2+ bound forms which ...

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Version:
2

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Department:
Structural Genomics
Role:
Researcher, Creator

Contributors

Department:
Balliol
Role:
Researcher
Department:
Structural Genomics
Role:
Researcher
Department:
Structural Genomics
Role:
Principal Investigator
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Grant:
106169/ZZ14/Z
Funding agency for:
Project
Publisher:
University of Oxford
Publication date:
2018

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