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Endotoxin signaling in human macrophages: signaling via an alternate mechanism.

Abstract:

Lipopolysaccharide (LPS) signals through Toll-like receptors (TLRs) in the course of sepsis, resulting in the release of inflammatory factors. In cell lines and murine models, parts of the signaling pathways involved have been elucidated with MyD88, Mal/TIRAP and IKK2 playing an important role in the induction of NF-kappaB. By focusing on primary human cells, we have shown that there are fundamental signaling differences between human and murine macrophages and between cells of myeloid and no...

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Publication status:
Published

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Publisher copy:
10.1179/096805104225005878

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of endotoxin research
Volume:
10
Issue:
6
Pages:
445-452
Publication date:
2004-01-01
DOI:
EISSN:
1743-2839
ISSN:
0968-0519
Source identifiers:
224124

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