The effect of erythrocyte antigen structure on requirement for T cells.

Journal article

The induction in mice of a humoral immune response to intact sheep erythrocytes, both in vivo and in vitro, requires participation of thymus derived (T) lymphocytes. In an in vitro system, spleen cells from both neonatally thymectomized and adult thymectomized irradiated bone marrow protected mice were successfully immunized, using washed sonicated sheep erythrocyte membrane fragments as antigen. This obviation of the requirement for T lymphocytes in the immune response, coupled with previous...

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Authors: Byrd, W; Feldmann, M; Palmer, J

• Journal: Immunology
• Volume: 27
• Issue: 2
• Pages: 331-337
• Publication date: 1974-08-01
• EISSN: 1365-2567
• ISSN: 0019-2805
• Language: English
• Keywords: Sheep; Antibody-Producing Cells; Immune Sera; Male; Cell Membrane; Microscopy, Electron; Female; Culture Techniques; Cattle; B-Lymphocytes; Centrifugation; Antibody Formation; Bone Marrow Cells; Erythrocytes; Thymectomy; Bone Marrow; Animals; Macrophages; Epitopes; Spleen; Sonication; Antigens; Radiation Effects; Radiation Chimera; Mice; T-Lymphocytes