Differences in the chromatin structure and cis-element organization of the human and mouse GATA1 loci: implications for cis-element identification.

Journal article

Cis-element identification is a prerequisite to understand transcriptional regulation of gene loci. From analysis of a limited number of conserved gene loci, sequence comparison has proved a robust and efficient way to locate cis-elements. Human and mouse GATA1 genes encode a critical hematopoietic transcription factor conserved in expression and function. Proper control of GATA1 transcription is critical in regulating myeloid lineage specification and maturation. Here, we compared sequence a...

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Authors: Valverde-Garduno, V; Guyot, B; Anguita, E; Hamlett, I; Porcher, C

• Publication status: Published
• Journal: Blood
• Volume: 104
• Issue: 10
• Pages: 3106-3116
• Publication date: 2004-11-01
• DOI: 10.1182/blood-2004-04-1333
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Enhancer Elements, Genetic; Genetic Complementation Test; Species Specificity; Humans; Transcription Factors; Molecular Sequence Data; Mice; Deoxyribonuclease I; GATA1 Transcription Factor; Acetylation; Animals; Myeloid Cells; Erythroid-Specific DNA-Binding Factors; Chromatin; DNA-Binding Proteins; Histones; Base Sequence; Chromosome Mapping