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Thesis

A genetic modifier of B6.YPOS gonadal sex reversal on chromosome 13

Abstract:

Sex determination is the process by which the embryonic gonad differentiates into either a testis or an ovary. When the mammalian gonad first arises in the embryo, the cells comprising it are bipotential: they can adopt a testiscular or ovarian fate. Such commitment is governed chromosomally, principally by the presence or absence of the Y chromosome. Testis determination in the mouse is initiated by the expression of the Y-linked gene, Sry. The timing of Sry expression is critical: if there ...

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Catherine Livermore More by this author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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