- Abstract:
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Sex determination is the process by which the embryonic gonad differentiates into either a testis or an ovary. When the mammalian gonad first arises in the embryo, the cells comprising it are bipotential: they can adopt a testiscular or ovarian fate. Such commitment is governed chromosomally, principally by the presence or absence of the Y chromosome. Testis determination in the mouse is initiated by the expression of the Y-linked gene, Sry. The timing of Sry expression is critical: if there ...
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- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Copyright date:
- 2018
Thesis
A genetic modifier of B6.YPOS gonadal sex reversal on chromosome 13
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