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The genomic and immune landscapes of lethal metastatic breast cancer

Abstract:

The detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsies from 10 patients with therapy-resistant breast cancer. The integrated genomic and immune landscapes show that metastases propagate and evolve as communities of clones, reveal their predicted neo-antigen landscapes, and show that they can accumulate HLA l...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.celrep.2019.04.098

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0002-6838-0711
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Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
27
Issue:
9
Pages:
2690-2708.e10
Publication date:
2019-05-28
Acceptance date:
2019-04-22
DOI:
EISSN:
2211-1247
Pubs id:
pubs:1007371
URN:
uri:c56bff59-dc1f-461c-a612-2ea045f881f6
UUID:
uuid:c56bff59-dc1f-461c-a612-2ea045f881f6
Local pid:
pubs:1007371

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