- Abstract:
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The detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsies from 10 patients with therapy-resistant breast cancer. The integrated genomic and immune landscapes show that metastases propagate and evolve as communities of clones, reveal their predicted neo-antigen landscapes, and show that they can accumulate HLA l...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 7.5MB)
-
- Publisher copy:
- 10.1016/j.celrep.2019.04.098
-
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- Publisher:
- Cell Press Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 27
- Issue:
- 9
- Pages:
- 2690-2708.e10
- Publication date:
- 2019-05-28
- Acceptance date:
- 2019-04-22
- DOI:
- EISSN:
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2211-1247
- Pubs id:
-
pubs:1007371
- URN:
-
uri:c56bff59-dc1f-461c-a612-2ea045f881f6
- UUID:
-
uuid:c56bff59-dc1f-461c-a612-2ea045f881f6
- Local pid:
- pubs:1007371
- Copyright holder:
- De Mattos-Arruda et al.
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Journal article
The genomic and immune landscapes of lethal metastatic breast cancer
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