Journal article icon

Journal article

Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin.

Abstract:

OBJECTIVE: A major site of action for the atheroprotective drug nicotinic acid (NA) is adipose tissue, via the G-protein-coupled receptor, GPR109A. Since, adipose tissue is an active secretory organ that contributes both positively and negatively to systemic inflammatory processes associated with cardiovascular disease, we hypothesized that NA would act directly upon adipocytes to alter the expression of pro-inflammatory chemokines, and the anti-inflammatory adipokine adiponectin. METHODS AN...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Atherosclerosis
Volume:
209
Issue:
1
Pages:
89-95
Publication date:
2010-03-01
DOI:
EISSN:
1879-1484
ISSN:
0021-9150
Language:
English
Keywords:
Pubs id:
pubs:20110
UUID:
uuid:c56bc3ec-945e-4ddb-90c6-4c6f7a004571
Local pid:
pubs:20110
Source identifiers:
20110
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP