D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).

Journal article

D-serine is an endogenous N-methyl-D-aspartate (NMDA) receptor coagonist. It is synthesized from L-serine by serine racemase (SRR), but many aspects of its metabolism remain unclear, especially in the forebrain, which lacks active D-amino acid oxidase (DAO), the major D-serine degradative enzyme. Candidate mechanisms include SRR operating in alpha,beta-eliminase mode (converting D-serine to pyruvate) and regulation by serine transport, in which the alanine-serine-cysteine transporter ASCT2 is...

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Authors: Sikka, P; Walker, R; Cockayne, R; Wood, M; Harrison, P

• Publication status: Published
• Journal: Journal of neuroscience research
• Volume: 88
• Issue: 8
• Pages: 1829-1840
• Publication date: 2010-06-01
• DOI: 10.1002/jnr.22332
• EISSN: 1097-4547
• ISSN: 0360-4012
• Language: English
• Keywords: RNA Interference; Amino Acid Transport System ASC; Dose-Response Relationship, Drug; Pyruvic Acid; Tritium; Gene Expression Regulation, Neoplastic; Serine; RNA, Messenger; Glioma; D-Amino-Acid Oxidase; Cell Line, Tumor; Racemases and Epimerases; Rats; Proline; Animals