Journal article
TPC2-mediated Ca2+ signaling is required for the establishment of synchronized activity in developing zebrafish primary motor neurons
- Abstract:
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During the development of the early spinal circuitry in zebrafish, spontaneous Ca2+ transients in the primary motor neurons (PMNs) are reported to transform from being slow and uncorrelated, to being rapid, synchronized and patterned. In this study, we demonstrated that in intact zebrafish, Ca2+ release via two-pore channel type 2 (TPC2) from acidic stores/endolysosomes is required for the establishment of synchronized activity in the PMNs. Using the SAIGFF213A;UAS:GCaMP7a double-transgenic z...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Accepted manuscript, pdf, 7.0MB)
-
- Publisher copy:
- 10.1016/j.ydbio.2018.02.011
Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Developmental Biology Journal website
- Volume:
- 438
- Issue:
- 1
- Pages:
- 57-68
- Publication date:
- 2018-03-23
- Acceptance date:
- 2018-02-21
- DOI:
- EISSN:
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1095-564X
- ISSN:
-
0012-1606
- Pmid:
-
29577882
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:834119
- UUID:
-
uuid:c55f524f-c210-4a8e-8b09-e12f0294f8a2
- Local pid:
- pubs:834119
- Source identifiers:
-
834119
- Deposit date:
- 2019-06-27
Terms of use
- Copyright holder:
- Elsevier Inc
- Copyright date:
- 2018
- Notes:
- © 2018 Elsevier Inc. This is an author version of the article. The final version is available online from the publisher's website.
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