Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans.

Journal article

BACKGROUND: Age and host genetics are important determinants of malaria severity. Lymphotoxin-alpha (LTalpha) has been associated with the development of cerebral malaria (CM) and other severe malaria (SM) syndromes. Mutations in genes regulating LTalpha production contribute to other acute vascular diseases and may contribute to malaria pathogenesis. METHODS: We tested the association between rs7291467, a single-nucleotide polymorphism (SNP) in the LTalpha-related gene encoding galectin-2 (L...

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Authors: Randall, L; Kenangalem, E; Lampah, D; Tjitra, E; Mwaikambo, E

• Publication status: Published
• Journal: Journal of infectious diseases
• Volume: 202
• Issue: 1
• Pages: 117-124
• Publication date: 2010-07-01
• DOI: 10.1086/653125
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: Child; Adolescent; Adult; Malaria, Falciparum; Aged; Introns; Indonesia; Case-Control Studies; Polymorphism, Single Nucleotide; Young Adult; Genetic Markers; Middle Aged; Galectin 2; Humans; Age Distribution; Child, Preschool; Genetic Predisposition to Disease; Infant