Expression Profiling of Proliferation and Apoptotic Markers along the Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis Patients

Journal article

Introduction. Familial adenomatous polyposis (FAP) patients have a germline mutation in the adenomatous polyposis coli (APC) gene. The APC protein interacts with beta-catenin, resulting in the activation of the Wnt signalling pathway. This results in alterations in cell proliferation and apoptosis. We investigated the expression of beta-catenin and related proliferation and apoptotic factors in FAP patients, exploring the expression along the adenoma-carcinoma sequence. Methods. The expressio...

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Authors: Wang, J; El-Masry, N; Talbot, I; Tomlinson, I; Alison, MR

• Publication status: Published
• Journal: GASTROENTEROLOGY RESEARCH AND PRACTICE
• Volume: 2013
• Pages: 1-7
• Publication date: 2013-01-01
• DOI: 10.1155/2013/107534
• EISSN: 1687-630X
• ISSN: 1687-6121
• Language: English