Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells.

Journal article

Naturally occurring FOXP3(+) CD4(+) Treg have a crucial role in self-tolerance. The ability to generate similar populations against alloantigens offers the possibility of preventing transplant rejection without indefinite global immunosuppression. Exposure of mice to donor alloantigens combined with anti-CD4 antibody induces operational tolerance to cardiac allografts, and generates Treg that prevent skin and islet allograft rejection in adoptive transfer models. If protocols that generate Tr...

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Authors: Francis, R; Feng, G; Tha-In, T; Lyons, I; Wood, K

• Publication status: Published
• Journal: European journal of immunology
• Volume: 41
• Issue: 3
• Pages: 726-738
• Publication date: 2011-03-01
• DOI: 10.1002/eji.201040509
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: T-Lymphocytes, Regulatory; Th1 Cells; Mice, Inbred CBA; Tissue Donors; Heart Transplantation; Skin Transplantation; Mice, Transgenic; Transplantation Tolerance; Cell Differentiation; Mice, Inbred DBA; CD4-Positive T-Lymphocytes; Isoantigens; Islets of Langerhans Transplantation; Forkhead Transcription Factors; Transplantation, Homologous; Mice; Adoptive Transfer; Graft Rejection; Mice, Inbred C57BL; Mice, Knockout; Animals