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Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease.

Abstract:

BACKGROUND: The development of disease-modifying therapies for Alzheimer's disease is hampered by our lack of understanding of the early pathogenic mechanisms and the lack of early biomarkers and risk factors.We have documented the expression pattern of mTOR regulated genes in the frontal cortex of Alzheimer's disease patients. We have also examined the functional integrity of mTOR signaling in peripheral lymphocytes in Alzheimer's disease patients relative to healthy controls. RESULTS: In th...

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Publisher copy:
10.1186/2051-5960-1-3

Authors


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Journal:
Acta neuropathologica communications
Volume:
1
Issue:
1
Pages:
3
Publication date:
2013-01-01
DOI:
EISSN:
2051-5960
ISSN:
2051-5960
Source identifiers:
440154
Language:
English
Pubs id:
pubs:440154
UUID:
uuid:c54a23c1-1d95-42d7-98d7-b7e086838395
Local pid:
pubs:440154
Deposit date:
2013-12-13

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