Journal article icon

Journal article

NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1.

Abstract:

Base excision repair is the major pathway for the repair of oxidative DNA damage in human cells that is initiated by a damage-specific DNA glycosylase. In human cells, the major DNA glycosylases for the excision of oxidative base damage are OGG1 and NTH1 that excise 8-oxoguanine and oxidative pyrimidines, respectively. We find that both enzymes have limited activity on DNA lesions located in the vicinity of the 3' end of a DNA single-strand break, suggesting that other enzymes are involved in...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/nar/gki816

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
Journal:
Nucleic acids research
Volume:
33
Issue:
15
Pages:
4849-4856
Publication date:
2005-01-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:c53a393f-6b4e-416b-bc33-9f380f9d474e
Source identifiers:
131264
Local pid:
pubs:131264

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP