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Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication

Abstract:

Problems that arise during DNA replication can drive genomic alterations that are instrumental in the development of cancers and many human genetic disorders. Replication fork barriers are a commonly encountered problem, which can cause fork collapse and act as hotspots for replication termination. Collapsed forks can be rescued by homologous recombination, which restarts replication. However, replication restart is relatively slow and, therefore, replication termination may frequently occur ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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10.7554/eLife.25490.001

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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Author
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Department:
Oxford, MSD, Biochemistry
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Author
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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Author
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Funding agency for:
Whitby, M
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
6
Pages:
Article: e25490
Publication date:
2017-06-06
Acceptance date:
2017-05-22
DOI:
ISSN:
2050-084X
Pubs id:
pubs:698585
URN:
uri:c53900a3-19d5-48f9-9e5a-0e0c2aca0d08
UUID:
uuid:c53900a3-19d5-48f9-9e5a-0e0c2aca0d08
Local pid:
pubs:698585

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