Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.

Journal article

Rap1 is a small, Ras-like GTPase that was first identified as a protein that could suppress the oncogenic transformation of cells by Ras. Rap1 is activated by several extracellular stimuli and may be involved in cellular processes such as cell proliferation, cell differentiation, T-cell anergy and platelet activation. At least three different second messengers, namely diacylglycerol, calcium and cyclic AMP, are able to activate Rap1 by promoting its release of the guanine nucleotide GDP and i...

Expand abstract

Authors: de Rooij, J; Zwartkruis, F; Verheijen, M; Cool, R; Nijman, S

• Publication status: Published
• Journal: Nature
• Volume: 396
• Issue: 6710
• Pages: 474-477
• Publication date: 1998-12-01
• DOI: 10.1038/24884
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: 3T3 Cells; Humans; Amino Acid Sequence; CHO Cells; Cloning, Molecular; Cyclic AMP-Dependent Protein Kinases; Rats; Signal Transduction; Guanine Nucleotide Exchange Factors; Cyclic AMP; Cell Line; Cricetinae; Mice; Animals; GTP-Binding Proteins; rap GTP-Binding Proteins; ras Guanine Nucleotide Exchange Factors; Molecular Sequence Data; Proteins; Forskolin