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Assessing sex-differences and the effect of timing of vaccination on immunogenicity, reactogenicity and efficacy of vaccines in young children: study protocol for an individual participant data meta-analysis of randomised controlled trials

Abstract:
Introduction: Disease incidence differs between males and females for some infectious or inflammatory diseases. Sex-differences in immune responses to some vaccines have also been observed, mostly to viral vaccines in adults. Little evidence is available on whether sex-differences occur in response to immunisation in infancy even though this is the age group in which most vaccines are administered. Factors other than sex, such as timing or co-administration of other vaccines,... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1136/bmjopen-2016-011680

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care, Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care, Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care, Primary Care Health Sciences
Role:
Author
Publisher:
BMJ Publishing Group Publisher's website
Journal:
BMJ Open Journal website
Volume:
6
Issue:
7
Pages:
1-5
Publication date:
2016-07-29
Acceptance date:
2016-07-04
DOI:
ISSN:
2044-6055
URN:
uuid:c524b506-03e2-42d1-8f94-32d68ad3ea74
Source identifiers:
633915
Local pid:
pubs:633915

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