Immunological and biochemical correlates of adjunctive dexamethasone in Vietnamese adults with bacterial meningitis.

Journal article

Adjunctive treatment to improve outcome from bacterial meningitis has centered on dexamethasone. Among Vietnamese patients with bacterial meningitis, cerebrospinal fluid (CSF) opening pressure and CSF:plasma glucose ratios were significantly improved and levels of CSF cytokines interleukin (IL)-6, IL-8, and IL-10 and were all statistically significantly lower after treatment in patients who were randomized to dexamethasone, compared with levels in patients who received placebo.

Authors: Mai, N; Tuan, T; Wolbers, M; Hoang, D; Nga, T

• Publication status: Published
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• Volume: 49
• Issue: 9
• Pages: 1387-1392
• Publication date: 2009-11-01
• DOI: 10.1086/630207
• EISSN: 1537-6591
• ISSN: 1058-4838
• Language: English
• Keywords: Interleukin-10; Asian Continental Ancestry Group; Dexamethasone; Adolescent; Anti-Inflammatory Agents; Young Adult; Interleukin-8; Vietnam; Interleukin-6; Humans; Adult; Female; Male; Meningitis, Bacterial; Child; Middle Aged